2023-1-79-90

УДК 616.211/.23-002-036-08:578.834.1]:577.164.2

DOI: https://doi.org/10.52540/2074-9457.2023.1.79

М. Р. Конорев, Н. Р. Прокошина, Т. М. Соболенко

РОЛЬ ВИТАМИНА С В АДЪЮВАНТНОЙ ТЕРАПИИ ВИРУСНЫХ ИНФЕКЦИЙ ВЕРХНИХ ДЫХАТЕЛЬНЫХ ПУТЕЙ И COVID-19: РЕАЛИИ И ПЕРСПЕКТИВЫ. ЧАСТЬ 1

Витебский государственный ордена Дружбы народов медицинский университет, г. Витебск, Республика Беларусь

Витамин С обладает известными антиоксидантными, противовоспалительными и иммуномодулирующими свойствами. Данный витамин является безрецептурным препаратом, который традиционно применяют для снижения риска развития и лечения респираторных инфекций. В то же время целесообразность использования витамина С для адъювантной терапии вирусных инфекций дыхательных путей до настоящего времени остается предметом научных исследований и дискуссий. В первой части обзора представлены современные данные о биологической роли и фармакологических свойствах витамина С, нормах потребления и пищевых источниках, а также дефиците и токсичности витамина. Рассмотрены результаты клинических исследований, систематических обзоров и мета-анализов по применению витамина С для профилактики и лечения инфекций верхних дыхательных путей.

Ключевые слова: витамин С, аскорбиновая кислота, инфекции верхних дыхательных путей, COVID-19, SARS-CoV-2.

SUMMARY

M. R. Konorev, N. R. Prakoshyna, T. M. Sabalenka

THE ROLE OF VITAMIN C IN THE ADJUVANT THERAPY OF VIRAL UPPER RESPIRATORY TRACT INFECTIONS AND COVID-19: REALITY AND PROSPECTS.
PART 1

Vitamin C possesses well-known antioxidant, anti-inflammatory and immunomodulating properties. This vitamin is an over-the-counter preparation traditionally used to reduce the risk of developing and to treat the respiratory infections. At the same time advisability of using vitamin C for adjuvant therapy of viral respiratory tract infections is still the subject of scientific research and discussions up to the present moment. The first part of the review presents current data on the biological role and pharmacological properties of vitamin C, consumption rates and food sources, as well as deficiency and toxicity of the vitamin. The results of the clinical studies, systematic reviews and meta-analyses on the use of vitamin C for the prevention and treatment of the upper respiratory tract infections are considered.

Keywords: vitamin C, ascorbic acid, upper respiratory tract infections, COVID-19, SARS-CoV-2.

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Адрес для корреспонденции:

210009, Республика Беларусь,

г. Витебск, пр. Фрунзе, 27,

УО «Витебский государственный ордена

Дружбы народов медицинский университет»,

кафедра общей и клинической фармакологии

с курсом ФПК и ПК,

тел. раб.: 8 (0212) 58-13-87,

Конорев М. Р.

Поступила 20.03.2023 г.