УДК 612.392.69:616-084
DOI: https://doi.org/10.52540/2074-9457.2025.2.65
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М. Р. Конорев, Н. Р. Прокошина, Т. М. Соболенко

ЦИНК: ОТ ПРОФИЛАКТИКИ ДЕФИЦИТА ДО ТЕРАПЕВТИЧЕСКОГО ПОТЕНЦИАЛА. ЧАСТЬ 2

Витебский государственный ордена Дружбы народов медицинский университет, г. Витебск, Республика Беларусь

 

Дефицит цинка, широко распространенный во всем мире, оказывает неблагоприятное воздействие на здоровье человека. Недостаток данного микроэлемента может отягощать течение различных заболеваний, сопровождающихся окислительным стрессом и процессом воспаления. Учитывая разнообразные функции цинка в организме, в последние годы возрос интерес исследователей к изучению его терапевтического потенциала. Во второй части обзора проанализированы результаты мета-анализов, систематических обзоров и клинических исследований за последние 10 лет по изучению возможности применения препаратов цинка при ряде патологических состояний. Представлены исследования по оценке положительного влияния добавок цинка на репродуктивное здоровье мужчин и женщин, снижение риска младенческой смертности, параметры роста и развития детей. Учитывая неблагоприятные последствия дефицита цинка в период беременности, обсуждается целесообразность использования добавок цинка у женщин с низким его потреблением. Показаны потенциальные возможности применения препаратов цинка в терапии респираторных вирусных инфекций, включая Covid-19, сердечно-сосудистых заболеваний, сахарного диабета, ожирения, заболеваний кожи. Рассмотрены перспективы биообогащения цинком продуктов питания для коррекции нарушений кишечной микробиоты.

Ключевые слова: цинк, дефицит цинка, репродуктивное здоровье, здоровье детей, инфекции верхних дыхательных путей, Covid-19, сердечно-сосудистые заболевания, сахарный диабет, ожирение, заболевания кожи, микробиота.

 

SUMMARY

R. Konorev, N. R. Prakoshyna, T. M. Sabalenka

ZINC: FROM DEFICIENCY PREVENTION TO THERAPEUTIC POTENTIAL. PART 2

Zinc deficiency widespread throughout the world has an adverse effect on human health. Lack of this microelement can aggravate the course of various diseases accompanied by oxidative stress and inflammation. Given the diverse functions of zinc in the body, in recent years, researchers have shown increasing interest in studying its therapeutic potential. The second part of the review analyzes the results of meta-analyses, systematic reviews and clinical studies over the past 10 years on the possibility of using zinc preparations in a number of pathological conditions. Studies are presented to assess the positive effect of zinc supplements on the reproductive health of men and women reducing the risk of infant mortality, and growth and development parameters in children. Given the adverse effects of zinc deficiency during pregnancy, the advisability of using zinc supplements in women with low zinc intake is discussed. The potential uses of zinc preparations in the treatment of the respiratory viral infections, including Covid-19, cardiovascular diseases, diabetes, obesity, and skin diseases are shown. The prospects of biofortification of food products with zinc to correct intestinal microbiota disorders are considered.

Keywords: zinc, zinc deficiency, reproductive health, children's health, upper respiratory tract infections, Covid-19, cardiovascular diseases, diabetes mellitus, obesity, skin diseases, microbiota.

 

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Адрес для корреспонденции:

210009, Республика Беларусь,

г. Витебск, пр. Фрунзе, 27,

УО «Витебский государственный ордена

Дружбы народов медицинский университет»,

кафедра общей и клинической фармакологии

с курсом ФПК и ПК,

тел. раб.: 8 (0212) 58 13 87,

Конорев М. Р.

Поступила 06.06.2025 г.